To Sleep or Not to Sleep:
Gaining Control of Your Sleep Rhythm
Did you get enough sleep this past week? Can you remember the last time you woke up without an alarm and feeling refreshed? If the answer to any of these questions is “no,” you are not alone. In fact, two-thirds of adults throughout all developed nations fail to obtain the recommended eight hours of sleep per night.
Did you know that routinely sleeping less than six or seven hours a night devastates your immune system, and more than doubles your risk of cancer? A lack of sleep is a key lifestyle determiner of whether or not you will develop Alzheimer’s disease. It also increases the likelihood of your coronary arteries becoming blocked and brittle, resulting in cardiovascular disease, stroke and congestive heart failure. Sleep disruption also further contributes to all major psychiatric conditions including depression, anxiety and suicidality.
Why is it Important?
As you can see, getting enough sleep is absolutely, mind-blowingly essential for mental and physical well-being. But why does sleep matter? Besides stealing our time, what does sleep really do for us?
Important for Brain Function
Sleep plays a vital role in brain function. A lack of sleep affects memory, learning abilities, mental clarity and emotional intelligence. Sleep deprivation has been linked to numerous neurological and psychiatric conditions including Alzheimer’s disease, anxiety, depression, bipolar disorder, suicide, stroke, and chronic pain. A prevailing view in psychiatry has been that mental disorders cause sleep disruption. However, studies have demonstrated that it’s not just a one-way street, that otherwise healthy people can experience a neurological pattern of brain activity similar to that observed in many of these psychiatric conditions simply by having their sleep disrupted.1 In fact, many of the brain regions commonly impacted by psychiatric mood disorders are the same regions that are involved in sleep regulation and impacted by sleep loss. By improving sleep quantity, quality and regularity, it is possible to significantly improve symptoms in psychiatric populations.
When it comes to Alzheimer’s disease for example, it’s interesting to note that sleep disturbance precedes the onset of Alzheimer’s disease by several years, suggesting that it may be an early warning sign of the condition, or perhaps even a contributing factor.2 Following diagnosis, the severity of sleep deprivation will then progress in linear fashion to the neurological symptoms of the Alzheimer’s patient. And finally, over 60% of Alzheimer patients have at least one clinical sleep disorder, insomnia being the most common.
Helps to Reduce your risk of Type 2 Diabetes
The link between sleep loss and abnormal blood sugar levels first emerged in a series of large epidemiological studies spanning several continents.3 Independent of one another, the researchers found far higher rates of type 2 diabetes among individuals that reported sleeping less than six hours a night routinely. Even when adjusting for other contributing factors such as body weight, alcohol consumption, smoking, age, gender, race and caffeine use, the association remained significant.4
The less you sleep, the more you are likely to eat. In addition, your body becomes unable to manage those calories effectively, especially the build up of sugar in your bloodstream. This is because in a sleep-deprived state, the cells of the body become far less receptive to insulin. The cells begin to repel rather than absorb the dangerously high levels of glucose. Sleeping less than 7 or 8 hours a night significantly increases your likelihood of developing type 2 diabetes.
Helps to Regulate your Appetite
Research has shown that inadequate sleep decreases the concentrations of the satiety-signalling hormone, leptin and increases levels of the hunger-instigating hormone, ghrelin.5 So lack of sleep mutes the chemical message that tells us to stop eating and increases the urge to keep eating.
Another recent discovery is that sleep loss increases levels of circulating endocannabinoids which are chemicals produced by the body which, like cannabis, stimulate appetite and increase your desire to snack. This increase in endocannabinoids combined with the changes in leptin and ghrelin levels caused by inadequate sleep form a potent storm, driving you in one direction: overeating. This sets up the potential for metabolic syndrome and obesity.6
Reduces your Risk of Cardiovascular Issues
Recent research shows that lack of sleep can increase your risk of cardiovascular issues via its impact on the sympathetic nervous system. In a 2004 Japanese study of 2,282 male workers, those sleeping less than six hours over a 14 year period were 300 to 400% more likely to suffer one or more cardiac arrests than those sleeping between 7-8 hours.7 In 2011, another study was done which tracked just less than half a million men and women of varied ages, race and ethnicities across eight different countries. Progressively shorter sleep was associated with 45% increased risk of developing and/or dying from coronary heart disease within 7 to 25 years from the start of the study.8 Both these studies took into account other cardiac risk factors such as smoking, physical activity and body mass.
A study has shown that you don’t need a full night of total sleep deprivation to inflict a significant impact on your cardiovascular system. Even just one night of losing 1 to 2 hours of sleep will quicken the contracting rate of a person’s heart and significantly increase their systolic blood pressure.9 Beyond accelerating your heart rate and increasing your blood pressure, a lack of sleep can also mean you are more likely to suffer calcification of your coronary arteries, significantly increasing your risk of a coronary heart attack.
Sleep also supports the optimal functioning of your reproductive system and hormones. In a study done at the University of Chicago, a group of young males were allowed to sleep for only five hours for one week.10 The researchers found a significant drop in their testosterone relative to their own baseline levels of testosterone when fully rested. In fact, the researchers concluded that the hormonal blunting effect is so large that it effectively “ages” a man by ten to fifteen years! Men suffering from sleep disorders, especially sleep apnoea associated with snoring, have markedly lower levels of testosterone than those of similar age and backgrounds who do not suffer from a sleep condition. Lack of sleep also affects sperm count and quality.
Inadequate sleep also affects the reproductive system of women. Routinely sleeping less than six hours a night results in a 20% drop in follicular-releasing hormone in women which is a hormone that peaks just prior to ovulation and is necessary for conception.11 In a report that brought together findings from studies over the past forty years of more than 100,000 employed women, those working irregular night-time hours who had poor-quality sleep, had a 33% higher rate of abnormal menstrual cycles than those working regular daytime hours.12 Moreover, the women working erratic hours were 80% more likely to suffer from issues of sub-fertility and reduced ability to get pregnant. Women who do become pregnant and routinely sleep less than 8 hours a night are also significantly more likely to suffer a miscarriage in the first trimester relative to those consistently sleeping eight hours or more a night.
Supports your Immune System and Reduces Your Risk of Cancer
Poor quality sleep can also suppress your immune function, negatively affecting the balance of bacteria in the gut and increasing inflammation. In fact, studies have shown that not enough sleep and poor sleep quality can leave your immune system more susceptible to infectious illnesses like the common cold.13 During sleep, your body releases more cytokines which are proteins needed to fight an infection or to reduce inflammation. If you don’t get enough sleep, your body produces less cytokines, making you more susceptible to infection. In addition, infection-fighting antibodies and cells are reduced during these periods when you don’t get enough sleep.
A study done at the University of California showed just how rapidly and comprehensively a brief dose of short sleep can affect your cancer fighting immune cells. The researchers found that a single night of four hours sleep in a cohort of healthy young men, swept away 70% of the natural killer cells circulating in the immune system, relative to a full eight-hour seep.14 It has also been discovered that night-time shift work, and the disruption to circadian rhythms and sleep that it causes, considerably increases the risk of developing numerous different forms of cancer. In fact, Denmark recently became the first country to pay worker compensation to women who had developed breast cancer after years of night shift work in government-sponsored jobs such as nurses or air cabin crew.
Helps You Live Longer
Last but not least, sleep also helps you live longer. A 2014 study published in Frontiers in Aging Neuroscience concluded that getting routine good quality sleep is a significant factor in achieving longer life spans. The researchers found that human longevity is associated with regular sleep patterns, maintenance of slow wave sleep and favourable lipid profile which was also impacted by sleep.15 By also increasing your risk of developing many chronic diseases, sleep deprivation has the ability to shorten your life expectancy.
Deep Sleep Formula
Deep Sleep Formula features time-tested and scientifically proven ingredients that will ensure that you get the rest you need to be well and stay well. Poor quality sleep and not getting enough sleep lead to physical and mental health problems and reduced life expectancy. Inadequate rest also causes imbalances in the microbiome and fuels inflammation. Prescription sleep medicines only provide short-term relief and cause dangerous and inconvenient side effects. Sleep Formula safely restores healthy sleep rhythms without side effects or dependency.
How Does it Work?
Sleep is a very complex process inside your body. It is regulated by the body’s circadian rhythm where your body thrives on exposure to light during the day and darkness at night. In the morning, your body, releases cortisol which helps wake you up and at night-time, when it gets dark, it releases melatonin, which helps you relax and go to sleep. Melatonin is released by the pineal gland. The release of these two hormones are governed by the suprachiasmatic nucleus (SCN), located in the hypothalamus, which is commonly referred to as the ‘master clock.’ The SCN receives communication from melanopsin (a photo pigment of the eye) which contains cells that respond to either the natural light or darkness.16
As well as cortisol and melatonin, a number of neurotransmitters are also critical to healthy sleep function including:17
- GABA is the main inhibitory neurotransmitter in switching off the state of wakefulness. It is critically involved in regulating neurons to coordinate the process of actually falling to sleep.
- Adenosine promotes sleep by influencing various sleep-wake pathways in the brain. For example, it inhibits regions of your brain which are tasked with keeping the brain awake.
- Dopamine also plays an important role in waking you up and keeping you awake during the day by downregulating melatonin.
- Acetylcholine the main neurochemical which helps to initiate REM sleep or the period of sleep during which you usually dream and have the most brain activity.
- Norepinephrine is one of your brain’s “ready for action” chemicals. It increases your brain’s level of arousal and helps to contribute to your state of wakefulness throughout the day. It also helps to trigger waking up from REM sleep.
- Glutamate is your primary excitatory neurotransmitter helps to regulate sleep duration.
In a normal circadian rhythm, there are many cycles and stages of sleep. Each sleep cycle lasts around 80 to 120 minutes and is repeated three to five times per night, delivering seven to eight hours of sleep per night. Two different stages include rapid-eye movement (REM) and non-rapid eye movement (NREM) sleep. REM stage is when you may recall your dreams the next day or even feel like you are falling asleep and is the stage when your brain is doing lots of rebooting! NREM sleep is the deepest level of sleep and this is when your brain is very inactive and where the majority of cerebral repair and restoration occurs.
How Much Sleep Should You Get?
As we have seen, research shows that getting too little and too much sleep can increase your risk of cardiovascular disease and reduce your life span. In fact, a 2017 study found that a “sweet spot” of approximately seven hours per night is optimal for the health and functioning of most adults. However, there may be differences based on your age, gender, health, activity level and genetic makeup.18
You may have noticed that as you got older, you needed less sleep than when you were a child. Newborn babies for example, typically need 14-17 hours of sleep per day and pre-schoolers need 10-13 hours. Teens typically require 8-10 hours per day.
There are various dietary and lifestyle factors that can increase the risk of getting inadequate sleep or poor sleep quality. These include:
- Caffeine and sugar
Especially if consumed later in the day, can keep you awake at night and make it difficult to fall asleep in the first place. Caffeine is an adenosine antagonist which means that it prevents adenosine from doing its job of getting you to fall asleep.
While alcohol in small amounts may help you get to sleep, research has shown that a high alcohol intake results in increased sleep disruption, lower quality of sleep and shorter sleep duration.
- Spicy and acidic foods
For some people, spicy foods like citrus and tomatoes can cause indigestion and reflux, making it difficult to get comfortable. This is especially true if you’ve eaten late right before you go to bed. It can also make you more likely to wake up at night.
- Poor sleep routines and exposure to blue light
Exposure to blue light can increase the risk of getting inadequate sleep or poor sleep quality.
- Poor gut health
The more inflamed our gut lining and the lower diversity of bacteria in our gut, the higher our overall inflammation will be which can interfere with our sleep.
When there is a drop in blood glucose levels, it causes the release of hormones that regulate glucose levels. These compounds stimulate the brain that it is time to eat, leading to a disruption in sleep.
- Hormone imbalance
Our sleep hormones which regulate our circadian rhythm are affected by all our other hormones including insulin, progesterone, oestrogen, testosterone, cortisol and adrenaline- if any of them are out of whack, there’s a good chance they are going to affect your sleep hormones.
- Being overweight
Being overweight can affect the structure of your respiratory pathways in your nose and throat, which can lead to snoring, mouth breathing and sleep apnoea issues.
- Shift work and jet lag
Changing our circadian rhythm affects how we sleep and can have a dramatic impact on our health both in the short-term and long-term.
The more cortisol and adrenaline your body produces during the day, the more likely your circadian rhythm will become dysregulated.
So let’s start talking about what foods to eat and what lifestyle strategies you can adopt to enhance your ability to fall asleep and enjoy a good night’s rest.
The Best Diet for a Good Night’s Sleep
The best foods to eat for sleep include:
Nuts and seeds
Walnuts, especially, are high in melatonin and can increase your body’s melatonin levels. Other nuts and seeds which are high in tryptophan, the precursor to melatonin include pistachios, almonds, pumpkin seeds and sesame seeds.
Beans and legumes
Beans and legumes are also natural sources of melatonin as well as tryptophan.
Bananas are rich in tryptophan and cherries are high in melatonin. Cherries are also known to significantly reduce inflammation and oxidative stress which help to improve sleep patterns. Kiwi may improve sleep onset, duration and quality among adults with sleep problems.20
Protein can help to prevent hypoglycaemia at night by balancing your blood sugar levels and preventing you from waking up throughout the night.
Tea such as chamomile, peppermint, lavender, lemon balm, valerian and passionflower- Teas can reduce inflammation and anxiety and act as natural sedatives.
Plant-based milks especially warmed up, may be soothing at night-time and promote sleep onset. Soy or almond milk may be especially useful as they are a good source of tryptophan
Water prevents you from becoming dehydrated and promotes restful sleep. Don’t drink too much though right before bed as then you’ll be getting up during the night to go to the toilet!
The Calm Kit
Other Ways to Improve your Sleep
Paying attention to sleep hygiene is one of the most straightforward ways that you can set yourself up for a good sleep. Strong sleep hygiene means having both a bedroom environment and daily routine that promotes consistent, uninterrupted sleep. It’s all about making positive habits that make it easier to sleep soundly throughout the night and wake up refreshed.
- Set your sleep schedule
Having a set schedule normalises sleep as an essential part of your daily routine and gets your brain and body accustomed to getting the full amount of sleep that you need. Make sure you have a fixed wake-up time regardless of whether it’s a weekday or weekend. If you want to shift your sleep times, don’t try to do it all at once. It’s better to make small, step-by-step adjustments of up to an hour or two so you can slowly get adjusted to a new schedule. Also, try not to overdo it with naps as it can throw out sleep at night. If you have to nap, keep them relatively short and limited to the early afternoon.
- Follow a nightly routine
How you prepare for bed can determine how easily you’ll be able to fall asleep. Give yourself 30 minutes to wind down before you sleep and take advantage of whatever puts you in a state of calm such as soft music, light stretching, reading or meditation exercises.
- Make sure your room is dark and at the right temperature.
Make sure your room is dark and at the right temperature. It’s best to have a window open so that you have good air flow.
- Turn off any blue lights
Turn off any blue lights and don’t give in to the temptation to look at your screens before you close your eyes. Light can hinder the production of melatonin and cell phones, tablets and laptops cause mental stimulation that is hard to shut off.
- Be comfortable
Make sure your mattress is comfortable and you have the right amount of blankets for body warmth.
- Don’t toss and turn
It helps to have a healthy mental connection between being in bed and actually being asleep. For that reason, if after twenty minutes, you haven’t gotten to sleep, get up and stretch, read or do something else that is calming in low light before trying to fall asleep again.
Have protein at night in combination with essential fatty acids (EFAs) to enable sufficient relaxation (protein is made up of amino acids including L-tryptophan which plays an important role in serotonin and melatonin synthesis). Protein may also stabilise blood sugars and prevent hypoglycaemia at night and EFAs are required structurally for neuronal membrane health as well as for production and regulation of prostaglandins that promote and suppress sleep
- Ensure that night-time meals are light and easily digestible
Ensure that night-time meals are light and easily digestible. If you’ve ever eaten a heavy meal near bedtime, you may have noticed that it can make it harder to fall asleep. It also might wake you up during the night.
- Avoid all stimulants
Avoid all stimulants especially in the hours before bedtime such as caffeine, alcohol, sugar and artificial sweeteners.
1 Krause, A. J., Simon, E. B., Mander, B. A., Greer, S. M., Saletin, J. M., Goldstein-Piekarski, A. N., & Walker, M. P. (2017). The sleep-deprived human brain. Nature reviews. Neuroscience, 18(7), 404–418. https://doi.org/10.1038/nrn.2017.55
2 Lloret, M. A., Cervera-Ferri, A., Nepomuceno, M., Monllor, P., Esteve, D., & Lloret, A. (2020). Is Sleep Disruption a Cause or Consequence of Alzheimer's Disease? Reviewing Its Possible Role as a Biomarker. International journal of molecular sciences, 21(3), 1168. https://doi.org/10.3390/ijms21031168
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12 Walker, M. (2017). Why We Sleep. Penguin Books, pp. 180.
13 Cohen, S., Doyle, W. J., Alper, C. M., Janicki-Deverts, D., & Turner, R. B. (2009). Sleep habits and susceptibility to the common cold. Archives of internal medicine, 169(1), 62–67. https://doi.org/10.1001/archinternmed.2008.505
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15 Mazzotti, D. R., Guindalini, C., Moraes, W. A., Andersen, M. L., Cendoroglo, M. S., Ramos, L. R., & Tufik, S. (2014). Human longevity is associated with regular sleep patterns, maintenance of slow wave sleep, and favorable lipid profile. Frontiers in aging neuroscience, 6, 134. https://doi.org/10.3389/fnagi.2014.00134
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28 Chandrasekhar, K., Kapoor, J., & Anishetty, S. (2012). A prospective, randomized double-blind, placebo-controlled study of safety and efficacy of a high-concentration full-spectrum extract of ashwagandha root in reducing stress and anxiety in adults. Indian journal of psychological medicine, 34(3), 255–262. https://doi.org/10.4103/0253-7176.106022
29 Abourashed ,E.A., Koetter, U., & Brattström, A. (2004). In vitro binding experiments with a valerian, hops and their fixed combination extract (ze91019) to selected central nervous system receptors. Phytomedicine, 11(7–8):633–638
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31 Klemow, K.M., Bartlow, A., Crawford, J., et al. (2011). Medical Attributes of St. John’s Wort (Hypericum perforatum) In: Benzie IFF, Wachtel-Galor S, editors. Herbal Medicine: Biomolecular and Clinical Aspects. 2nd edition. Boca Raton (FL): CRC Press/Taylor & Francis. Chapter 11. Available from: https://www.ncbi.nlm.nih.gov/books/NBK92750/
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